Gene Silencer

Scientists at Harvard Medical School and Boston Children's Hospital have identified a mechanism that regulates the imprinting of multiple genes, including some of those critical to placental growth during early embryonic development in mice.

A surprising new link between inflammation and mental illness — and a potential drug to protect the brain

Up to 75 percent of patients with systemic lupus erythematosus, an incurable autoimmune disease commonly known as “lupus”, experience neuropsychiatric symptoms. Michael Carroll's lab set out to uncover the mechanisms underlying lupus’ effects on the brain and made a surprising finding that points to a potential new drug for protecting the brain from the neuropsychiatric effects of lupus.

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On Friday, March 17th, Dr. Xuetao Cao delivered the 2017 Edwin J. Cohn lecture, titled "Innate Immune Molecules in Inflammation and Cancer." Hosted by PCMM, the event was held in the Armenise Amphitheater.

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Transfusing engineered red blood cells to protect against autoimmune disease

Scientists at Boston Children’s Hospital, MIT and the Whitehead Institute think they may have found a targeted way to protect the body from autoimmune disease. Their approach, published in Proceedings of the National Academy of Sciences, uses transfusions of engineered red blood cells to re-train the immune system.

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Seeking a way to keep organs young

A study by Dr. Denisa Wagner and her team, published recently by the Journal of Experimental Medicine, pinpoints a gene responsible for fibrosis and identifies some possible therapeutic solutions.

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UTX makes NKT

Published this week in Nature Immunology, the Winau lab in collaboration with Stuart Orkin’s group revealed how the histone demethylase UTX regulates the development of natural killer T cells through multiple epigenetic mechanisms.

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Modulation of Scramblase: a novel paradigm to fight chronic infection and cancer

Reporting this week in JEM, the Winau lab identified a new pathway involving scramblase TMEM16F that preserves efficient T cell responses to control viral infection. These findings provide a novel target for therapy against chronic diseases, such as cancer, HIV and hep B virus infections.

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Keeping up with HIV mutations: Building a nimble vaccine test system

A group led by Frederick Alt, developed a technology to greatly speed up HIV development in mice. The group’s method generates mouse models with built-in human immune systems. The model rapidly recapitulates what the human immune system does, enabling researchers to continuously test and tweak potential HIV vaccines.

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CD1a molecule as a potential therapeutic target in inflammatory skin diseases

The Winau Lab has discovered a new mechanism for skin inflammation. This work, recently published in Nature Immunology, forms the basis for future therapeutic strategies against inflammatory skin diseases, such as poison ivy dermatitis and psoriasis.

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When antibiotics fail: A potential new angle on severe bacterial infection and sepsis

Reporting this week in Nature, scientists in Boston Children’s Hospital’s Program in Cellular and Molecular Medicine (PCMM) describe new potential avenues for controlling both sepsis and the runaway bacterial infections that provoke it.

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Democratizing high-throughput single molecule force analysis

Now, a research team led by Wesley Wong has made a major advance by developing an inexpensive method that permits analysis of the force responses of thousands of similar molecules simultaneously.

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DNA breaks in nerve cells' ancestors cluster in specific genes

Study reveals new avenue for thinking about brain development, brain tumors and neurodevelopmental/psychiatric diseases

 

Featured News Story

Gene Silencer

Gene Silencer

A biological process known as genomic imprinting helps control early mammalian development by turning genes on and off as the embryo and placenta grow.
Errors in genomic imprinting can cause severe disorders and profound developmental defects that lead to lifelong health problems, yet the mechanisms behind these critical gene-regulating processes-and the glitches that cause them to go awry-are not well understood.

Now, scientists at Harvard Medical School and Boston Children's Hospital have identified a mechanism that regulates the imprinting of multiple genes, including some of those critical to placental growth during early embryonic development in mice.

The results are reported July 19 in the journal Nature.

If affirmed in further animal and in human studies, the findings could pave the way to epigenetic therapies for a range of devastating… Read More »

Announcements

Jun (Jacob) Hu was awarded Cancer Research Institute Irvington Post-doctoral Fellowship

Jun (Jacob) Hu was awarded Cancer Research Institute…

Congratulations to Dr. Jun Hu, who has each been awarded a post-doctoral fellowship from the Cancer Research Institute (CRI).Jun Jacob Hu, a postdoctoral fellow in the Hao… Read More »

Yang Li awarded Career Development Fellowship by Boston Children's Hospital

Yang Li awarded Career Development Fellowship by Boston…

NLRP3 inflammasome is a multiprotein assembly responsible for activation of inflammatory process through the recognition of a broad spectrum of signals. Autosomal dominant mutations in the NLRP3 expressing… Read More »

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